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RE: A Landmark 16th Century World Map by the Guy the Invented the Atlas... Abraham Ortelius
The Spanish conquered the Mexican mainland by the early 1500s and Cortez actually reached La Paz by 1535. He was looking for a fabled gold city, but only discovered black pearls. Bummer...
A later expedition was led by Juan Cabrillo in 1542, but that would be the last European venture into the area until the end of the 1500s.