Travellers, I have a luggage question for you

What's the best carry on luggage for frequent travellers?

I normally use a backpack, which is awesome and has served me well over the last 10 years. But I find myself taking more work and work/leisure trips so I feel the need for a change.

What am I looking for?

Something that looks a bit smarter, durable and well designed. Ideally a two piece carry on set that I can carry on. I generally avoid checking in luggage.

Lots of compartments for various gadgets is a definite requirement.

Budget is flexible

Any suggestions?

Usual blurb: vote, resteem etc. But most importantly, comment. I want to know what you think, don't be shy!