Problem is you can't patent a natural remedy like you can a pharmaceutical. Hence, it will never be as profitable,
For this reason, it will never be mainstream and like you said you need to do your own research.
Generally, natural remedies have less side effects, but, all comes down to:
what Paracelsus said — "All things are poisons, for there is nothing without poisonous qualities. It is only the dose which makes a thing poison."