RE: Pin1 - Using Cystallography & NMR structures in Pymol to unveil a proteins function & structure

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RE: Pin1 - Using Cystallography & NMR structures in Pymol to unveil a proteins function & structure

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davidrhodes124 (60)in #science • 6 years ago

The name "Pin1" has (unfortunately) also been used for a plant protein, and I think this may be a potential source of confusion in the literature. Pin1 in plants is involved in polar auxin (indole acetic acid) transport: Xi et al. Pin1At regulates PIN1 polar localization and root gravitropism. Nature Communications 7: 10430 (2016). I believe that this plant "Pin1" has a completely different structure, but please correct me if I am wrong. I look forward to following your posts in the future.

6 years ago in #science by davidrhodes124 (60)

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clausewitz (60) 6 years ago (edited)

Yeah this seems solid, its about Pin1at, and the PIN in this article refers to: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812941/ an abbreviation for something else.

You are right they are very different Pin1 vs PIN which comes in versions 1-7 :)

Thanks for the contribution I appreciate it, so no confusion strikes, should someone stumble on another PIN1, the auxin transport proteins, PIN 1,2,3,4,5,6 or 7 or pin1at in palnts for that matter.
The structures I used, are expressed in models systems, with human gene sequence as template.

Although studies in metazoans have advanced our understanding of PIN1-type PPIases, the biological roles of their orthologues in plants are still largely unknown. In a previous study, we have shown that the only Arabidopsis orthologue of PIN1-type PPIases, Pin1At

The article only mentioned Pin1 here, so I get the possible confusion! PPias-type :)

Root gravitropism allows plants to establish root systems and its regulation depends on polar auxin transport mediated by PIN-FORMED (PIN) auxin transporters

The opening statement explains the PIN abbreviation. The only link from PIN to Pin1 is that a Pin1 similar protein called Pin1at activates or regulates PIN ergo PIN-FORMED :)

Pin1at, the orthologue in the studie. Lacks WW domain here, but are similar!

Thanks again, good information to have here :)

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