Pharma Skeletons - A message to the pharmaceutical lobbying group PhRMA

This is to good not to post... LULZ!!!

Welcome to Pharma Skeletons, by Martin Shkreli. Email [email protected]

Stephen Ubl,

Don't you dare point your finger at me for the pharmaceutical industry's troubles. It turns out we've all made some unpopular moves. Here are some from PhRMA's member companies. Note that Mylan and Roche/Genentech are not a member companies.

Abbvie/Abbott

Abbott raised the price of an HIV drug, Norvir, (sound familiar?) to huge public outcry.

People were pissed.

They didn't need to. Abbott had billions of dollars of net income that year.

Abbott still raises the price of Humira, every year. This is despite Humira being the best selling drug on the planet.

Allergan

Allergan pretends 10% price increases make sense in a no-inflation environment. Just assume no one can do math. A big price increase on a small product is worse than small increases on big products, right?

Just paid the SEC a ton of cash to settle allegations it wasn't disclosing M&A events properly.

We pulled Namenda IR off the market so that we could greedily switch patients to Namenda XR.

But everyone else is the bad actor, not us.

Don't forget the inversion to avoid taxes, as well as their attempt to reverse merge with Pfizer to take them out of the U.S. tax system as well.

Remember that this is the company that does not do any R&D -- they buy-in and call that "open science". Open bullshit. No 'lab coats' here.

Amag

Does Makena ring a bell? Is PhRMA basically a price gouging trade group? What lab coats does this company don?

Amgen

No price increases here! No scientists either! Just lawyers.

<a href="http://blogs.sciencemag.org/pipeline/archives/2017/01/06/12104" Even village idiot Matt Herper refers to the company as a "law firm with a biotech attached"

Company was accused of pushing EPO so hard that it became toxic to patients. Remember that?

The company hasn't had a science-oriented CEO in decades. Their R&D productivity is pathetic.

Avanir

We sell... cough syrup? We got a patent on the cough syrup for pseudobulbar affect. Somehow it got FDA approved.

It's not a big selling drug or anything, but we need lobbying.

Bayer

We raise prices on drugs by 100%+ but no one notices.

'Member Baycol? Oh, I member.

Biogen

Price increases power this shitty business.

Tecfidera was a cheap drug available overseas.

New drug costs $750,000 its first year and ~$300,000 every year thereafter. Daraprim is $25,000 one time. Get mad!

Biogen doesn't fool anyone into thinking they're "innovative".

Biomarin

Kuvan doesn't cost much in Europe.

Bristol-Myers

Is anyone old enough to 'member old Bristol Myers? Vanlev? Richard Lane? Peter Dolan? I 'member.

It sure is easy to pretend you're a model citizen if you're willing to ignore that your company went through a pretty ugly period fifteen years ago.

Celgene

So we took a really old drug, price increased that by a lot.

Then we made PRODRUGS of that drug and priced them even higher.

THEN we increased the prodrug EVEN MORE.

Eli Lilly

No price increases to speak of. Model citizen.

Except Cialis which mysteriously has the same price changes as Viagra.

There were some allegations Lilly "overpromoted" Zyprexa, but I wouldn't know anything about that.

Esperion

We don't even sell drugs yet but we spend shareholder money on lobbying.

Genentech

Andy Pollack wrote a story in the New York Times in 1988 complaining about the high price of Activase.

Some things never change.

With that said, Genentech is an awesome science-driven company who had a card-carrying scientist CEO.

But you should also look into the history of the guy who was there before Dr. Levinson.

Man, what a scumbag.

GlaxoSmithKline

Do we even do pharma anymore? Consumer head now runs our business.

We sold off our crappy old drugs to "price gougers". Ever stop to think about who sold Daraprim to me?

Why didn't ethical GSK hold on to it? I wonder why these big drug companies dump their old, small drugs...

Horizon

LOLOLOLOLOLOLOL. Deep breath. Resume laughing. LOLOLOLOLOL.

PHRMA is defending the poster child of price increases?

Doing a Freidreich's study that couldn't have worked doesn't count as R&D that will magically absolve you.

Horizon is another tax avoider. Ireland headquarters. So much pharma talent there. So many lab coats.

Jazz

This is a really smart shareholder-focused company. But if you are looking for the vanguard of R&D, keep looking.

Jazz is another "Dublin" headquartered company.

Johnson & Johnson

J&J has had a very hard time making their OTC medicines. I seem to remember something about Tylenol a long time ago...

Anyone remeber Scios?

Writing about J&J transgressions will take some time.

Lundbeck

Because when your patent is expiring: TRY THE ISOMER!

Mallinckrodt / Questcor

Really? Acthar's 65,000% price increase represents your values but Turing doesn't?

Gosh, I'm so upset my portfolio companies aren't a part of your trade group.

I sued & whistleblew this company after they bought the only competitor to their only drug in order to stop my competition from their high price.

Tax avoider? Check. Ireland.

Marathon

Bro. These guys invented price increases. I literally learned it from them.

Ovation. I can sell & start a new company, too.

Merck / Schering-Plough

There was once a drug called Vioxx. I member Vioxx.

CEO is a lawyer. He was in senior management during the Vioxx scandal and was promoted.

Schering-Plough consent decree was an interesting time.

There was also some Vytorin controversy if I recall correctly.

Mylan

Mylan did nothing wrong! Their tiny profit margin and pedestrian price increase was only relevant because people know the brand "EpiPen". You never heard of "Acthar", eh?

Novartis / Sandoz / Ciba-Geigy / Alcon

Maybe the one honest, well-run company in pharma?

Novo Nordisk

Some price increases here if you look hard enough. Like, if you look at all.

Orexigen

This company is barely solvent. Come on, what are you lobbying for?

I suggest they spend less money on dues and try to get profitable.

Pfizer / Wyeth / Pharmacia / Warner-Lambert

They raise price sometimes.

One of the most unproductive R&D groups in the history of pharmaceuticals. Those lab coats!

Torcetrapib. Bapinezumab.

"Pfizer fined $106 million fine for imposing a 2600% price hike"

Purdue

I know absolutely no one who blames this company for the opioid epidemic.

I doubt they even promote OxyContin.

Sanofi

Couple of price increases here, I think.

Reasonable company overall, to be frank.

Just a reminder.

You: Washington Lobbyist piece of shit.

Me: A guy who has done R&D and started two drug companies. When you learn what a nitrogen atom is, you can talk about me.

USPTO 8673883

USPTO 9181286

Turing is a small company researching drugs for rare diseases that no one else wants to. All of your member companies, with a few humorous exceptions, have billions of dollars and don't need price increases. I'm sorry if my company's and patients' survival is inconvenient to your gigantic income streams.

Look in the mirror. This website took me half an hour to make, just 'membering a few moments from the past. Pharma is a wonderful industry that does great things, but trying to throw me under the bus is foolish. Let me remind you 90% of your members' CEOs could not hold a candle to me in scientific knowledge, achievements or wealth and entrepreneurial achievements.

90% of you are the same as you, Mr. Ubl, slick guys in suits who make a living spewing bullshit. Also keep in mind that I took a very low or zero salary at all of my companies. Your CEOs enjoy the fat paychecks they receive from price increases. I put my money from price increases into research. Half of big pharma CEOs could not tell you the first thing about science. Maybe focus on changing that before you point at me and make false statements.

Martin Shkreli

Founder of Turing Pharmaceuticals AG

Founder of Retrophin, Inc.

Co-Inventor of a new series of pantothenate analogs for the treatment of pantothenate kinase associated neurodegeneration, a lethal pediatric illness

Licensor and innovator of sparsentan, the first endothelin antagonist for focal segmental glomerulosclerosis, a rare pediatric kidney disease

Co-Inventor of a new series of molecules for the treatment of Canavan Disease

Co-Inventor of a new series of molecules for the treatment of Lafora Disease

Inventor of a fusion protein platform for the treatment of several rare genetic disorders

Co-Inventor of a potential treatment for SLO Syndrome

Ask about me. I wish you would.