I say "almost" because there is a way to break the closed feedback loop of this reality's chain of stimuli and reactions.

It would work like this: All our thoughts and actions within this reality domain are 100% deterministic, as one triggers the other etc etc. At some point, if say, new stimuli originates from outside this reality domain, the deterministic results are upset because an "uncertainty" has been introduced.

This can be as simple as having an intuition or a prophetic dream which was communicated from our "higher" / "spirit" self, which then shifts our actions to new directions - which are still deterministic reactions to our stimuli. But in the act of even having that intuition, the chain of equations that was predicting behavior is then broken because the "anomaly" was introduced and suddenly the end result changed to something different.

It would be pretty difficult to ascertain what is the state of affairs in the higher-order reality beyond this virtual reality because we have no idea how it works and if it can likewise experience a similar intervention from above (if it is in itself another virtual reality within a virtual reality). We can speculate though.