Yes your concience can be one with the Holy Spirit, such that the voice of your conscience and Holy Spirit speaks withone voice. This take place when you are fully united with Chist and becomes one with Him.
1 Corinthians 6:17 "boldBut he that is joined unto the Lord is one spirit."

That is, a state when your mind becomes that of Christ. "For we have the mind of Christ"
1 Corinthians 2:16 "boldFor who hath known the mind of the Lord, that he may instruct him? But we have the mind of Christ."